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Identification and Strategies to Mitigate High Total Clearance of Benzylamine-Substituted Biphenyl Ring Systems.
Williamson, Beth; McMurray, Lindsay; Boyd, Scott; Collingwood, Olga; McLean, Neville; Winter-Holt, Jon; Chan, Christina; Xue, Aixiang; McCoull, William.
Affiliation
  • Williamson B; Drug Metabolism and Pharmacokinetics, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • McMurray L; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Boyd S; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Collingwood O; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • McLean N; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Winter-Holt J; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Chan C; Drug Metabolism and Pharmacokinetics, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Xue A; R&D Clinical Pharmacology and Safety Sciences, AstraZeneca, Waltham 02451, United States.
  • McCoull W; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Mol Pharm ; 19(7): 2115-2132, 2022 07 04.
Article in En | MEDLINE | ID: mdl-35533086
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzylamines / Biphenyl Compounds / Hepatocytes / Models, Biological Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzylamines / Biphenyl Compounds / Hepatocytes / Models, Biological Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2022 Type: Article Affiliation country: United kingdom