[Advances in gut microbiomes and immunology of IgG4-related hepatobiliary and pancreatic diseases].
Zhonghua Gan Zang Bing Za Zhi
; 30(4): 452-456, 2022 Apr 20.
Article
in Zh
| MEDLINE
| ID: mdl-35545574
ABSTRACT
IgG4-related disease (IgG4-RD) is an immune-mediated condition associated with chronic fibroinflammatory lesions that can affect nearly any organ. IgG4-related hepatobiliary and pancreatic diseases are IgG4-RD involving the hepatobiliary and pancreatic system, which is characterized with elevated serum IgG4 concentrations, large numbers of IgG4 positive lymphoplasma cells infiltration in affected organs, storiform fibrosis, and imaging changes of organ morphology. Due to the lack of reliable biomarkers, histopathology is still an important basis for diagnosis. The pathogenesis of IgG4-related hepatobiliary and pancreatic diseases has not been clarified. This review focuses on the recent advances in intestinal microecology-immunology, host genetics-immunity and recurrence monitoring of IgG4-related hepatobiliary and pancreatic diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatic Diseases
/
Autoimmune Diseases
/
Gastrointestinal Microbiome
/
Immunoglobulin G4-Related Disease
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Gan Zang Bing Za Zhi
Journal subject:
GASTROENTEROLOGIA
Year:
2022
Type:
Article
Affiliation country:
China