Molecular Network Analyses Implicate Death-Associated Protein Kinase 3 (DAPK3) as a Key Factor in Colitis-Associated Dysplasia Progression.

Chen, Huey-Miin; MacDonald, Justin A

Chen, Huey-Miin; MacDonald, Justin A.

Affiliation

Chen HM; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
MacDonald JA; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Inflamm Bowel Dis ; 28(10): 1485-1496, 2022 10 03.

Article in En | MEDLINE | ID: mdl-35604388

Our investigation verified pancolitis as a conduit for ulcerative colitis advancement from left-sided colitis to dysplasia and uniquely identified dysregulation of actin reorganization, with death-associated protein kinase 3 and Yes-associated protein as key molecular determinants for disease progression.

Subject(s)

Colitis, Ulcerative; Colitis; Colonic Neoplasms; Actins/metabolism; Colitis/complications; Colitis, Ulcerative/complications; Colitis, Ulcerative/genetics; Colitis, Ulcerative/metabolism; Colonic Neoplasms/complications; Death-Associated Protein Kinases/metabolism; Ephrins/metabolism; Humans; Hyperplasia/complications; YAP-Signaling Proteins

Key words

colon cancer; death-associated protein kinase; differential-gene expression; dysplasia; ulcerative colitis; zipper-interacting protein kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Colitis / Colonic Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2022 Type: Article Affiliation country: Canada

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