Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study.
BMC Pediatr
; 22(1): 310, 2022 05 27.
Article
in En
| MEDLINE
| ID: mdl-35624438
ABSTRACT
BACKGROUND:
Childhood obesity has important effects on the onset and development of puberty. Although a number of studies have confirmed the relationship between obesity and precocious puberty, little is known about the pleiotropic genes of obesity and precocious puberty and the interaction between genes and environment. There are fourobjectives:
(1) to analyze the incidence of precocious puberty in the general population in China; (2) to verify the direct effect of obesity on children's precocious puberty using a variety of methods; (3) to verify the effect of obesity and its risk gene polymorphism on precocious puberty in a prospective cohort study; and (4) to analyze the interaction effect of genes and environment on pubertal development.METHODS:
We will conduct a multi-center prospective cohort study in three cities, which are selected in southern, central, and northern China, respectively. Primary schools in these cities will be selected by a stratified cluster random sampling method. Primary school students from grade 1 to grade 3 (6 to 10 years old) will be selected for the cohort with extensive baseline data collection, including assessment of pubertal development, family demographic information, early development, sleep pattern, dietary pattern, and physical activity. Participants will be followed up for at least three years, and long-term follow-up will depend on future funding.DISCUSSION:
The findings of this multicenter prospective population-based cohort study may expand previous related puberty development research as well as provide important information on the mechanism of early puberty. Targeted interventions can also be developed to improve adolescent health problems related to puberty development based on the available evidence. TRIAL REGISTRATION ClinicalTrials.gov Identifier NCT04113070 , prospectively registered on October 2, 2019.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Puberty, Precocious
/
Pediatric Obesity
Type of study:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Humans
Language:
En
Journal:
BMC Pediatr
Journal subject:
PEDIATRIA
Year:
2022
Type:
Article
Affiliation country:
China