Unmasking allosteric-binding sites: novel targets for GPCR drug discovery.

Casadó-Anguera, Verònica; Casadó, Vicent

Casadó-Anguera, Verònica; Casadó, Vicent.

Affiliation

Casadó-Anguera V; Laboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, and Institute of Biomedicine of the Universitat de Barcelona, Barcelona, Spain.
Casadó V; Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

Expert Opin Drug Discov ; 17(8): 897-923, 2022 08.

Article in En | MEDLINE | ID: mdl-35649692

Subject(s)

Drug Discovery; Receptors, G-Protein-Coupled; Allosteric Regulation; Allosteric Site; Binding Sites; Humans; Ligands; Protein Subunits; Receptors, G-Protein-Coupled/metabolism

Key words

Allostery; G protein-coupled receptor; allosteric drug; cooperativity; cross-antagonism; cross-talk; heteromer; hidden binding site; homomer; orthosteric drug

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, G-Protein-Coupled / Drug Discovery Limits: Humans Language: En Journal: Expert Opin Drug Discov Year: 2022 Type: Article Affiliation country: Spain

Fulltext

XML

PubMed Links

Search on Google