Introducing thymus for promoting transplantation tolerance.
J Allergy Clin Immunol
; 150(3): 549-556, 2022 09.
Article
in En
| MEDLINE
| ID: mdl-35690492
ABSTRACT
Establishing tolerance remains a central, if elusive, goal of transplantation. In solid-organ transplantation, one strategy for inducing tolerance has been cotransplantation of various forms of thymic tissue along with another organ. As one of the biological foundations of central tolerance, thymic tissue carries with it the ability to induce tolerance to any other organ or tissue from the same donor (or another donor tissue-matched to the thymic tissue) if successfully transplanted. In this review, we outline the history of this approach as well as work to date on its application in organ transplantation, concluding with future directions. We also review our experience with allogeneic processed thymus tissue for the treatment of congenital athymia, encompassing complete DiGeorge syndrome and other rare genetic disorders, and consider whether allogeneic processed thymic tissue implantation may offer a novel method for future experimentation with tolerance induction in organ transplantation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organ Transplantation
/
DiGeorge Syndrome
Limits:
Humans
Language:
En
Journal:
J Allergy Clin Immunol
Year:
2022
Type:
Article
Affiliation country:
New Caledonia