Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1&#945;-dependent expression of collagen I (&#945;2) during renal fibrosis.

Das, Falguni; Ghosh-Choudhury, Nandini; Maity, Soumya; Kasinath, Balakuntalam S; Choudhury, Goutam Ghosh

Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis.

Das, Falguni; Ghosh-Choudhury, Nandini; Maity, Soumya; Kasinath, Balakuntalam S; Choudhury, Goutam Ghosh.

Affiliation

Das F; VA Research, South Texas Veterans Health Care System, San Antonio, Texas, USA; Department of Medicine, UT Health, San Antonio, Texas, USA.
Ghosh-Choudhury N; Department of Pathology, UT Health, San Antonio, Texas, USA.
Maity S; Department of Medicine, UT Health, San Antonio, Texas, USA.
Kasinath BS; Department of Medicine, UT Health, San Antonio, Texas, USA.
Choudhury GG; VA Research, South Texas Veterans Health Care System, San Antonio, Texas, USA; Department of Medicine, UT Health, San Antonio, Texas, USA; Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, Texas, USA. Electronic address: choudhuryg@uthscsa.edu.

J Biol Chem ; 298(9): 102246, 2022 09.

Article in En | MEDLINE | ID: mdl-35835217

Subject(s)

Collagen Type I; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Oncogene Proteins; Protein Deglycase DJ-1; Animals; Collagen Type I/biosynthesis; Collagen Type I/genetics; Diabetes Mellitus, Experimental/complications; Diabetes Mellitus, Experimental/pathology; Diabetic Nephropathies/genetics; Diabetic Nephropathies/metabolism; Fibrosis; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Kidney/pathology; Mechanistic Target of Rapamycin Complex 1/metabolism; Mechanistic Target of Rapamycin Complex 2/metabolism; Oncogene Proteins/genetics; Oncogene Proteins/metabolism; Protein Deglycase DJ-1/genetics; Protein Deglycase DJ-1/metabolism; Protein Kinase C beta/metabolism; RNA, Small Interfering/metabolism; Rats; Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta/pharmacology

Key words

Diabetic nephropathy; Extracellular matrix protein; Fibrosis; PKC; TGFß; mTORC

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogene Proteins / Collagen Type I / Diabetes Mellitus, Experimental / Diabetic Nephropathies / Hypoxia-Inducible Factor 1, alpha Subunit / Protein Deglycase DJ-1 / Mechanistic Target of Rapamycin Complex 1 / Mechanistic Target of Rapamycin Complex 2 / Kidney Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2022 Type: Article Affiliation country: United States

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