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Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases.
Duru, Nadire; Pawar, Nisha R; Martin, Erik W; Buzza, Marguerite S; Conway, Gregory D; Lapidus, Rena G; Liu, Shihui; Reader, Jocelyn; Rao, Gautam G; Roque, Dana M; Leppla, Stephen H; Antalis, Toni M.
Affiliation
  • Duru N; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Pawar NR; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Martin EW; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Buzza MS; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Conway GD; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Lapidus RG; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Liu S; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Reader J; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Rao GG; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Roque DM; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Leppla SH; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Antalis TM; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201.
Proc Natl Acad Sci U S A ; 119(28): e2201423119, 2022 07 12.
Article in En | MEDLINE | ID: mdl-35867758
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Bacterial Toxins / Prodrugs / Serine Proteases / Antigens, Bacterial / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Bacterial Toxins / Prodrugs / Serine Proteases / Antigens, Bacterial / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article