A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication.

Kozhukhar, Natalya; Spadafora, Domenico; Rodriguez, Yelitza A R; Alexeyev, Mikhail F

Kozhukhar, Natalya; Spadafora, Domenico; Rodriguez, Yelitza A R; Alexeyev, Mikhail F.

Affiliation

Kozhukhar N; Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL 36688, USA.
Spadafora D; Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL 36688, USA.
Rodriguez YAR; Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL 36688, USA.
Alexeyev MF; Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL 36688, USA.

Cells ; 11(14)2022 07 11.

Article in En | MEDLINE | ID: mdl-35883613

Subject(s)

DNA-Binding Proteins; Transcription Factors; DNA, Mitochondrial/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Humans; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Reverse Genetics; Transcription Factors/genetics; Transcription Factors/metabolism

Key words

GeneSwap approach; TFAM; TFAM chimeras; TFAM knockout; TFAM-mtDNA evolutionary co-adaptation; mtDNA instability; mtDNA metabolism; mtDNA replication; mtDNA transcription

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cells Year: 2022 Type: Article Affiliation country: United States

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