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Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
Heo, Yunseok; Ishimoto, Naito; Jeon, Ye-Eun; Yun, Ji-Hye; Ohki, Mio; Anraku, Yuki; Sasaki, Mina; Kita, Shunsuke; Fukuhara, Hideo; Ikuta, Tatsuya; Kawakami, Kouki; Inoue, Asuka; Maenaka, Katsumi; Tame, Jeremy R H; Lee, Weontae; Park, Sam-Yong.
Affiliation
  • Heo Y; Structural Biochemistry & Molecular Biophysics Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
  • Ishimoto N; Research Center for Bioconvergence Analysis, Korea Basic Science Institute (KBSI), Chungbuk, Korea.
  • Jeon YE; Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan.
  • Yun JH; Structural Biochemistry & Molecular Biophysics Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
  • Ohki M; Structural Biochemistry & Molecular Biophysics Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
  • Anraku Y; PCG-Biotech, Ltd., Seoul, Korea.
  • Sasaki M; Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan.
  • Kita S; Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan.
  • Fukuhara H; Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan.
  • Ikuta T; Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan.
  • Kawakami K; Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan.
  • Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
  • Maenaka K; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
  • Tame JRH; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
  • Lee W; Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan.
  • Park SY; Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan.
PLoS Biol ; 20(8): e3001714, 2022 08.
Article in En | MEDLINE | ID: mdl-35913979
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Galanin / Heterotrimeric GTP-Binding Proteins / Receptor, Galanin, Type 2 Limits: Humans Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2022 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Galanin / Heterotrimeric GTP-Binding Proteins / Receptor, Galanin, Type 2 Limits: Humans Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2022 Type: Article