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An anti-CTLA-4 heavy chain-only antibody with enhanced Treg depletion shows excellent preclinical efficacy and safety profile.
Gan, Xin; Shan, Qianqian; Li, He; Janssens, Rick; Shen, Yuqiang; He, Yun; Chen, Fei; van Haperen, Rien; Drabek, Dubravka; Li, Jin; Zhang, Yang; Zhao, Jiuqiao; Qin, Beibei; Jheng, Ming-Jin; Chen, Victor; Wang, Jingsong; Rong, Yiping; Grosveld, Frank.
Affiliation
  • Gan X; Harbour BioMed, Shanghai 201203, China.
  • Shan Q; Harbour BioMed, Shanghai 201203, China.
  • Li H; Harbour BioMed, Shanghai 201203, China.
  • Janssens R; Harbour BioMed, Shanghai 201203, China.
  • Shen Y; Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
  • He Y; Harbour BioMed, Shanghai 201203, China.
  • Chen F; Harbour BioMed, Shanghai 201203, China.
  • van Haperen R; Harbour BioMed, Shanghai 201203, China.
  • Drabek D; Harbour BioMed, Shanghai 201203, China.
  • Li J; Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
  • Zhang Y; Harbour BioMed, Shanghai 201203, China.
  • Zhao J; Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
  • Qin B; Harbour BioMed, Shanghai 201203, China.
  • Jheng MJ; Harbour BioMed, Shanghai 201203, China.
  • Chen V; Harbour BioMed, Shanghai 201203, China.
  • Wang J; Harbour BioMed, Shanghai 201203, China.
  • Rong Y; Harbour BioMed, Shanghai 201203, China.
  • Grosveld F; Harbour BioMed, Shanghai 201203, China.
Proc Natl Acad Sci U S A ; 119(32): e2200879119, 2022 08 09.
Article in En | MEDLINE | ID: mdl-35925889
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Heavy Chains / T-Lymphocytes, Regulatory / Immunotherapy / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Heavy Chains / T-Lymphocytes, Regulatory / Immunotherapy / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: China