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Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health.
Gadd, Danni A; Hillary, Robert F; McCartney, Daniel L; Shi, Liu; Stolicyn, Aleks; Robertson, Neil A; Walker, Rosie M; McGeachan, Robert I; Campbell, Archie; Xueyi, Shen; Barbu, Miruna C; Green, Claire; Morris, Stewart W; Harris, Mathew A; Backhouse, Ellen V; Wardlaw, Joanna M; Steele, J Douglas; Oyarzún, Diego A; Muniz-Terrera, Graciela; Ritchie, Craig; Nevado-Holgado, Alejo; Chandra, Tamir; Hayward, Caroline; Evans, Kathryn L; Porteous, David J; Cox, Simon R; Whalley, Heather C; McIntosh, Andrew M; Marioni, Riccardo E.
Affiliation
  • Gadd DA; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Shi L; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
  • Stolicyn A; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK.
  • Robertson NA; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Walker RM; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, Edinburgh BioQuarter, Edinburgh, EH16 4SB, UK.
  • McGeachan RI; Centre for Discovery Brain Sciences, University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, UK.
  • Campbell A; The Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Edinburgh, EH25 9RG, UK.
  • Xueyi S; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Barbu MC; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK.
  • Green C; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK.
  • Morris SW; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK.
  • Harris MA; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Backhouse EV; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK.
  • Wardlaw JM; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, Edinburgh BioQuarter, Edinburgh, EH16 4SB, UK.
  • Steele JD; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, Edinburgh BioQuarter, Edinburgh, EH16 4SB, UK.
  • Oyarzún DA; Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
  • Muniz-Terrera G; UK Dementia Research Institute, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Ritchie C; Division of Imaging Science and Technology, Medical School, University of Dundee, Dundee, DD1 9SY, UK.
  • Nevado-Holgado A; School of Informatics, University of Edinburgh, Edinburgh, EH8 9AB, UK.
  • Chandra T; School of Biological Sciences, University of Edinburgh, Edinburgh, EH3 3JF, UK.
  • Hayward C; The Alan Turing Institute, 96 Euston Road, London, NW1 2DB, UK.
  • Evans KL; Centre for Clinical Brain Sciences, Edinburgh Dementia Prevention, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Porteous DJ; Department of Social Medicine, Ohio University, Athens, OH, 45701, USA.
  • Cox SR; Centre for Clinical Brain Sciences, Edinburgh Dementia Prevention, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Whalley HC; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
  • McIntosh AM; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Nat Commun ; 13(1): 4670, 2022 08 09.
Article in En | MEDLINE | ID: mdl-35945220
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteome / Genome-Wide Association Study Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteome / Genome-Wide Association Study Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Type: Article Affiliation country: United kingdom