All Quiet on the TE Front? The Role of Chromatin in Transposable Element Silencing.
Cells
; 11(16)2022 08 11.
Article
in En
| MEDLINE
| ID: mdl-36010577
ABSTRACT
Transposable elements (TEs) are mobile genetic elements that constitute a sizeable portion of many eukaryotic genomes. Through their mobility, they represent a major source of genetic variation, and their activation can cause genetic instability and has been linked to aging, cancer and neurodegenerative diseases. Accordingly, tight regulation of TE transcription is necessary for normal development. Chromatin is at the heart of TE regulation; however, we still lack a comprehensive understanding of the precise role of chromatin marks in TE silencing and how chromatin marks are established and maintained at TE loci. In this review, I discuss evidence documenting the contribution of chromatin-associated proteins and histone marks in TE regulation across different species with an emphasis on Drosophila and mammalian systems.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin
/
DNA Transposable Elements
Limits:
Animals
Language:
En
Journal:
Cells
Year:
2022
Type:
Article
Affiliation country:
France