Limited-stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study.
J Surg Oncol
; 126(8): 1396-1402, 2022 Dec.
Article
in En
| MEDLINE
| ID: mdl-36036894
ABSTRACT
BACKGROUND:
This study aimed to investigate the efficacy of surgery in the treatment of small cell carcinoma of the esophagus (SCCE) and explore potential prognostic factors.METHODS:
We screened patients with SCCE who underwent esophagectomy from 2010 to 2018 at three institutes. Differences in survival were analyzed using the Kaplan-Meier method and log-rank test. The prognostic factors were identified using univariate and multivariate analyses.RESULTS:
A total of 69 patients were included. Multivariate analysis showed that TNM stage (hazard ratio [HR] 4.10, 95% confidence interval [CI] 1.57-10.75, p = 0.004) and adjuvant therapy (HR 0.28, 95% CI 0.16-0.51, p < 0.001) were independent prognostic factors. Stage I, stage IIA, and stage IIB disease were merged into the surgery response disease (SRD), whereas stage III disease into the surgery nonresponse disease (SNRD). The SRD group had significantly improved survival compared to the SNRD group (HR 0.33, 95% CI 0.19-0.58, p < 0.001). In addition, adjuvant therapy increased survival benefit in the SNRD group (p < 0.001) but not in the SRD group (p = 0.061).CONCLUSIONS:
Surgery alone appears to be adequate for disease control in the SRD group, whereas multimodality therapy was associated with improved survival in the SNRD group.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Esophageal Neoplasms
/
Carcinoma, Small Cell
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Surg Oncol
Year:
2022
Type:
Article
Affiliation country:
China