Beyond nylon 6: polyamides via ring opening polymerization of designer lactam monomers for biomedical applications.
Chem Soc Rev
; 51(19): 8258-8275, 2022 Oct 03.
Article
in En
| MEDLINE
| ID: mdl-36047318
ABSTRACT
Ring opening polymerization (ROP) of lactams is a highly efficient and versatile method to synthesize polyamides. Within the last ten years, significant advances in polymerization methodology and monomer diversity are ushering in a new era of polyamide chemistry. We begin with a discussion of polymerization techniques including the most widely used anionic ring opening polymerization (AROP), and less prevalent cationic ROP and enzyme-catalyzed ROP. Next, we describe new monomers being explored for ROP with increased functionality and stereochemistry. We emphasize the relationships between composition, structure, and properties, and how chemists can control composition and structure to dictate a desired property or performance. Finally, we discuss biomedical applications of the synthesized polyamides, specifically as biomaterials and pharmaceuticals, with examples to include as antimicrobial agents, cell adhesion substrates, and drug delivery scaffolds.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anti-Infective Agents
/
Nylons
Language:
En
Journal:
Chem Soc Rev
Year:
2022
Type:
Article
Affiliation country:
United States