The chicken c-erbA proto-oncogene is preferentially expressed in erythrocytic cells during late stages of differentiation.
Mol Cell Biol
; 7(7): 2416-24, 1987 Jul.
Article
in En
| MEDLINE
| ID: mdl-3614196
ABSTRACT
We analyzed the expression of the c-erbA proto-oncogene in different tissues of chicken embryos. c-erbA transcripts were found at low levels in the lung, kidney, liver, and heart and in high amounts in embryonic blood cells. Nuclease mapping assays proved that these transcripts were true c-erbA transcripts. In situ hybridization on fractionated embryonic blood cells showed that c-erbA transcripts were predominantly found in erythroblasts, particularly during the final step of differentiation. Life span analysis of c-erbA mRNAs revealed their relative instability, demonstrating that the high level of c-erbA transcripts in embryonic erythroblasts was not the result of passive accumulation. These results suggest that the c-erbA genes play some role in erythrocyte differentiation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proto-Oncogenes
/
Gene Expression Regulation
/
Erythrocytes
Limits:
Animals
Language:
En
Journal:
Mol Cell Biol
Year:
1987
Type:
Article