Your browser doesn't support javascript.
loading
Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (Danio rerio) Model: Involvement of Cholinergic System and Brain Oxidative Stress.
Brinza, Ion; Raey, Mohamed A El; El-Kashak, Walaa; Eldahshan, Omayma A; Hritcu, Lucian.
Affiliation
  • Brinza I; Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I, No. 11, 700505 Iasi, Romania.
  • Raey MAE; Department of Phytochemistry and Plant Systematics, National Research Centre, Dokki, Cairo 12622, Egypt.
  • El-Kashak W; Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Cairo 12622, Egypt.
  • Eldahshan OA; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt.
  • Hritcu L; Center of Drug Discovery Research and Development, Ain Shams University, Abbassia, Cairo 11566, Egypt.
Molecules ; 27(18)2022 Sep 11.
Article in En | MEDLINE | ID: mdl-36144637
ABSTRACT
Sweroside is a secoiridoid glycoside and belongs to a large group of naturally occurring monoterpenes with glucose sugar attached to C-1 in the pyran ring. Sweroside can promote different biological activities such as antifungal, antibacterial, hepatoprotective, gastroprotective, sedative and antitumor, antioxidant, and neuroprotective activities. Zebrafish were given sweroside (12.79, 8.35, and 13.95 nM) by immersion once daily for 8 days, along with scopolamine (Sco, 100 µM) 30 min before the initiation of the behavioral testing to cause anxiety and memory loss. Employing the novel tank diving test (NTT), the Y-maze, and the novel object recognition test (NOR), anxiety-like reactions and memory-related behaviors were assessed. The following seven groups (n = 10 animals per group) were used control, Sco (100 µM), sweroside treatment (2.79, 8.35, and 13.95 nM), galantamine (GAL, 2.71 µM as the positive control in Y-maze and NOR tests), and imipramine (IMP, 63.11 µM as the positive control in NTT test). Acetylcholinesterase activity (AChE) and the antioxidant condition of the brains were also evaluated. The structure of sweroside isolated from Schenkia spicata was identified. Treatment with sweroside significantly improved the Sco-induced decrease of the cholinergic system activity and brain oxidative stress. These results suggest that sweroside exerts a significant effect on anxiety and cognitive impairment, driven in part by the modulation of the cholinergic system activity and brain antioxidant action.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scopolamine / Zebrafish Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Type: Article Affiliation country: Romania

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scopolamine / Zebrafish Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Type: Article Affiliation country: Romania