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Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties.
Amin, Kamelia M; El-Badry, Ossama M; Abdel Rahman, Doaa E; Abdellattif, Magda H; Abourehab, Mohammed A S; El-Maghrabey, Mahmoud H; Elsaid, Fahmy G; El Hamd, Mohamed A; Elkamhawy, Ahmed; Ammar, Usama M.
Affiliation
  • Amin KM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
  • El-Badry OM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University (ACU), Giza 12566, Egypt.
  • Abdel Rahman DE; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
  • Abdellattif MH; Department of Chemistry, College of Science, Taif University, Al-Haweiah, Taif 21944, Saudi Arabia.
  • Abourehab MAS; Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
  • El-Maghrabey MH; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia 61519, Egypt.
  • Elsaid FG; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
  • El Hamd MA; Biology Department, Science College, King Khalid University, Abha 61421, Saudi Arabia.
  • Elkamhawy A; Zoology Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
  • Ammar UM; Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.
Pharmaceutics ; 14(9)2022 Sep 15.
Article in En | MEDLINE | ID: mdl-36145702
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Pharmaceutics Year: 2022 Type: Article Affiliation country: Egypt
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Pharmaceutics Year: 2022 Type: Article Affiliation country: Egypt