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Nodules, nodes and non-functioning macrophages: A risk with ibrutinib therapy.
Melville, Peter; Mohammed, Farheena; RuiWen Kuo, Chris; Bradley, Jack; Preston, Gavin; Dempsey, Owen J.
Affiliation
  • Melville P; Department of Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.
  • Mohammed F; Department of Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.
  • RuiWen Kuo C; Department of Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.
  • Bradley J; Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.
  • Preston G; Department of Haematology, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.
  • Dempsey OJ; Department of Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.
J R Coll Physicians Edinb ; 52(1): 46-47, 2022 03.
Article in En | MEDLINE | ID: mdl-36146976
We describe the case of a 70-year-old never smoker with chronic lymphocytic leukaemia, treated with single agent ibrutinib therapy. Chest imaging noted nodular change and mediastinal lymphadenopathy, which showed avid uptake on positron emission tomography and guided subsequent biopsies (bronchoscopy using endobronchial ultrasound, mediastinoscopy). Despite negative aspergillus blood immunology tests, he was found to have invasive aspergillosis, which is a known risk with ibrutinib therapy. He has since been successfully treated with antifungal therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lung Neoplasms Type of study: Etiology_studies / Risk_factors_studies Limits: Aged / Humans / Male Language: En Journal: J R Coll Physicians Edinb Journal subject: EDUCACAO / HISTORIA DA MEDICINA / MEDICINA Year: 2022 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lung Neoplasms Type of study: Etiology_studies / Risk_factors_studies Limits: Aged / Humans / Male Language: En Journal: J R Coll Physicians Edinb Journal subject: EDUCACAO / HISTORIA DA MEDICINA / MEDICINA Year: 2022 Type: Article