Regioselective Synthesis of Indole-Fused Seven-Membered N-Heterocycles via Photoredox-Catalyzed Intramolecular Cyclization.
J Org Chem
; 87(21): 14394-14406, 2022 11 04.
Article
in En
| MEDLINE
| ID: mdl-36206145
ABSTRACT
Herein, we describe the construction of indole-fused seven-membered N- and O-heterocycles from indolyl α-diazocarbonyls via photoredox-catalyzed intramolecular cyclization. The photoredox process features operational simplicity, mild conditions, and as low as 0.1 mol % catalyst loading. The tricyclic heterocycles are obtained in yields of 24 to 67% with excellent regioselectivity. The practicality of this protocol is further demonstrated by gram-scale reactions carried out in both batch and continuous flow.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Indoles
Type of study:
Guideline
Language:
En
Journal:
J Org Chem
Year:
2022
Type:
Article
Affiliation country:
China