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Psychopharmacological Effects of Stimulation of the Functions of Neural Stem Cells by STAT3 Inhibitor under Conditions of Modeled Ethanol-Induced Encephalopathy.
Zyuz'kov, G N; Zhdanov, V V; Miroshnichenko, L A; Polyakova, T Yu; Stavrova, L A; Simanina, E V; Minakova, M Yu; Agafonov, V I; Churin, A A.
Affiliation
  • Zyuz'kov GN; Laboratory of Pathophysiology and Experimental Therapy, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. zgn@pharmso.ru.
  • Zhdanov VV; Laboratory of Pathophysiology and Experimental Therapy, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Miroshnichenko LA; Tomsk National Research State University, Tomsk, Russia.
  • Polyakova TY; Laboratory of Pathophysiology and Experimental Therapy, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Stavrova LA; Laboratory of Pathophysiology and Experimental Therapy, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Simanina EV; Laboratory of Pathophysiology and Experimental Therapy, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Minakova MY; Laboratory of Pathophysiology and Experimental Therapy, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Agafonov VI; Laboratory of Pathophysiology and Experimental Therapy, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Churin AA; Laboratory of Pathophysiology and Experimental Therapy, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Bull Exp Biol Med ; 173(5): 615-619, 2022 Sep.
Article in En | MEDLINE | ID: mdl-36210414
ABSTRACT
The psychopharmacological effects of a stimulator of functions of progenitor cells of the nervous tissue STAT3 inhibitor (STAT3 Inhibitor XIV, LLL12) were studied under conditions of modeled alcoholic encephalopathy in C57BL/6 mice. The pharmacological agent corrected the parameters of exploratory behavior (characterizing predominantly cognitive activity) in the experimental animals at the late terms of observation. At the same time, the reproducibility of the conditioned passive avoidance response developed at the beginning of the course STAT3 inhibitor administration decreased. These effects developed against the background of a significant increase in the content of neural stem cells and their proliferative activity in the paraventricular zone of the brain.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Diseases / Neural Stem Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2022 Type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Diseases / Neural Stem Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2022 Type: Article Affiliation country: RUSSIA