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Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia.
Pereira-Martins, Diego A; Coelho-Silva, Juan L; Weinhäuser, Isabel; Franca-Neto, Pedro L; Silveira, Douglas R; Ortiz, César; Moreira-Aguiar, Amanda; Lima, Marinus M; Koury, Luisa C; de Melo, Raul A; Glória, Ana B; Fagundes, Evandro M; Lino, Bruno K; Pagnano, Katia; Bittencourt, Rosane; Nunes, Elenaide; Traina, Fabiola; Figueiredo-Pontes, Lorena; Keating, Armand; Tallman, Martin S; Ribeiro, Raul C; Dilon, Richard; Ganser, Arnold; Sanz, Miguel A; Berliner, Nancy; Valk, Peter; Löwenberg, Bob; Ottone, Tiziana; Noguera, Nelida I; Voso, Maria T; Paoloni, Francesca; Fazi, Paola; Ammatuna, Emanuele; Huls, Gerwin; Schuringa, Jan Jacob; Rego, Eduardo M; Lucena-Araujo, Antonio R.
Affiliation
  • Pereira-Martins DA; Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  • Coelho-Silva JL; Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Weinhäuser I; Department of Medical Imaging, Haematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Franca-Neto PL; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.
  • Silveira DR; Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  • Ortiz C; Department of Medical Imaging, Haematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Moreira-Aguiar A; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.
  • Lima MM; Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Koury LC; Department of Medical Imaging, Haematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • de Melo RA; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.
  • Glória AB; Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  • Fagundes EM; Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
  • Lino BK; Department of Medical Imaging, Haematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Pagnano K; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.
  • Bittencourt R; Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  • Nunes E; Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  • Traina F; Department of Medical Imaging, Haematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Figueiredo-Pontes L; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.
  • Keating A; Department of Internal Medicine, University of Pernambuco, Recife, Brazil.
  • Tallman MS; Hematology Division, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Ribeiro RC; Hematology Division, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Dilon R; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil.
  • Ganser A; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil.
  • Sanz MA; Hematology Division, Federal University of Paraná, Curitiba, Brazil.
  • Berliner N; Hematology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Valk P; Department of Medical Imaging, Haematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Löwenberg B; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.
  • Ottone T; Department of Medical Imaging, Haematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Noguera NI; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.
  • Voso MT; Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Paoloni F; Leukemia Service, Memorial Sloan-Kettering Cancer Center/Weill Cornell Medical College, New York City, New York, USA.
  • Fazi P; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Ammatuna E; Department of Medical and Molecular Genetics, King's College London School of Medicine, London, UK.
  • Huls G; Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Schuringa JJ; Department of Hematology, Valencia University Medical School, Valencia, Spain.
  • Rego EM; CIBERONC, Instituto Carlos III, Madrid, Spain.
  • Lucena-Araujo AR; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Br J Haematol ; 200(2): 170-174, 2023 01.
Article in En | MEDLINE | ID: mdl-36263593
Although a growing body of evidence demonstrates that altered mtDNA content (mtDNAc) has clinical implications in several types of solid tumours, its prognostic relevance in acute promyelocytic leukaemia (APL) patients remains largely unknown. Here, we show that patients with higher-than-normal mtDNAc had better outcomes regardless of tumour burden. These results were more evident in patients with low-risk of relapse. The multivariate Cox proportional hazard model demonstrated that high mtDNAc was independently associated with a decreased cumulative incidence of relapse. Altogether, our data highlights the possible role of mitochondrial metabolism in APL patients treated with ATRA.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute Type of study: Prognostic_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2023 Type: Article Affiliation country: Brazil
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute Type of study: Prognostic_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2023 Type: Article Affiliation country: Brazil