Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction.

Radilová, Katerina; Zima, Václav; Král, Michal; Machara, Ales; Majer, Pavel; Hodek, Jan; Weber, Jan; Brynda, Jirí; Strmen, Timotej; Konvalinka, Jan; Kozísek, Milan

Radilová, Katerina; Zima, Václav; Král, Michal; Machara, Ales; Majer, Pavel; Hodek, Jan; Weber, Jan; Brynda, Jirí; Strmen, Timotej; Konvalinka, Jan; Kozísek, Milan.

Affiliation

Radilová K; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic; First Faculty of Medicine, Charles University, Katerinská 1660/32, 12108, Prague, 2, Czech Republic.
Zima V; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic; Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 12800, Prague, 2, Czech Republic.
Král M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic; First Faculty of Medicine, Charles University, Katerinská 1660/32, 12108, Prague, 2, Czech Republic.
Machara A; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic. Electronic address: ales.machara@uochb.cas.cz.
Majer P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic.
Hodek J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic.
Weber J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic.
Brynda J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic.
Strmen T; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic.
Konvalinka J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic; Department of Biochemistry, Faculty of Science, Charles University, Hlavova 8, 12800, Prague, 2, Czech Republic.
Kozísek M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 16610, Prague 6, Czech Republic. Electronic address: milan.kozisek@uochb.cas.cz.

Antiviral Res ; 208: 105449, 2022 12.

Article in En | MEDLINE | ID: mdl-36265804

Subject(s)

Influenza, Human; Humans; Influenza, Human/drug therapy; Protein Binding; RNA-Dependent RNA Polymerase; Peptides/pharmacology; Peptides/metabolism; Thermodynamics

Key words

AlphaScreen; Antiviral peptides; Influenza A polymerase; Isothermal titration calorimetry; Protein-protein interaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza, Human Limits: Humans Language: En Journal: Antiviral Res Year: 2022 Type: Article Affiliation country: Czech Republic

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