Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalization.
Catheter Cardiovasc Interv
; 100(6): 964-970, 2022 11.
Article
in En
| MEDLINE
| ID: mdl-36321612
ABSTRACT
BACKGROUND:
Angiography-based vessel fractional flow reserve (vFFR) demonstrated a strong correlation with invasive fractional flow reserve (FFR) in both a pre- and post-percutaneous coronary intervention (PCI) setting. However, the role of vFFR and its correlation with post-PCI FFR in chronic coronary occlusions (CTO) has not been evaluated yet. We sought to investigate the diagnostic performance of post-PCI vFFR with post-PCI FFR as a reference in patients undergoing successful CTO PCI.METHODS:
Between March 2016 and April 2020, a total of 80 patients from the FFR-SEARCH (prospective registry) and FFR REACT (randomized controlled trial) studies underwent successful CTO recanalization with post-PCI FFR measurements.RESULTS:
A total of 50 patients (median age 66 (interquartile range [IQR] 56-74) years, 76% were male) were eligible for the analysis. Median post-PCI FFR was 0.89 (IQR 0.84-0.94), while median post-PCI vFFR was 0.91 (IQR 0.85-0.94) (p 0.10). Suboptimal physiological results, defined as FFR and vFFR <0.90, were identified in 26 (52%) and in 21 (42%) patients, respectively. A strong correlation (r = 0.82) was found between vFFR and FFR with a mean bias of 0.013 ± 0.051. Receiver-operating characteristics curve analysis revealed an excellent accuracy of vFFR in predicting FFR <0.90 (area under the curve 0.97; 95% confidence interval 0.93-1.00).CONCLUSION:
Post-PCI vFFR shows a good correlation with post-PCI FFR and a high diagnostic accuracy for post-PCI FFR ≤0.90 in patients undergoing successful PCI of a CTO lesion.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
Fractional Flow Reserve, Myocardial
/
Percutaneous Coronary Intervention
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Catheter Cardiovasc Interv
Journal subject:
CARDIOLOGIA
Year:
2022
Type:
Article
Affiliation country:
Netherlands