Cerebral perfusion imaging predicts final infarct volume after basilar artery thrombectomy.
J Stroke Cerebrovasc Dis
; 32(1): 106866, 2023 Jan.
Article
in En
| MEDLINE
| ID: mdl-36427471
ABSTRACT
OBJECTIVES:
Cerebral perfusion imaging may be used to identify the ischemic core in acute ischemic stroke (AIS) patients with a large vessel occlusion of the anterior circulation; however, perfusion parameters that predict the ischemic core in AIS patients with a basilar artery occlusion (BAO) are poorly described. We determined which cerebral perfusion parameters best predict the ischemic core after successful endovascular thrombectomy (EVT) in BAO patients. MATERIALS ANDMETHODS:
We performed multicenter retrospective study of BAO patients with perfusion imaging before EVT and a DWI after successful EVT. The ischemic core was defined as regions on CTP, which were co-registered to the final DWI infarct. Various time-to-maximum (Tmax) and cerebral blood flow (CBF) thresholds were compared to final infarct volume to determine the best predictor of the final infarct.RESULTS:
28 patients were included in the analysis for this study. Tmax >8s (r2 0.56; median absolute error, 16.0 mL) and Tmax >10s (r2 0.73; median absolute error, 11.3 mL) showed the strongest agreement between the pre-EVT CTP study and the final DWI. CBF <38% (r2 0.76; median absolute error, 8.2 mL) and CBF <34% (r2 0.76; median absolute error, 9.1 mL) also correlated well with final infarct volume on DWI.CONCLUSIONS:
Pre-EVT CT perfusion imaging is useful to predict the final ischemic infarct volume in BAO patients. Tmax >8s and Tmax >10s were the strongest predictors of the post-EVT final infarct volume.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Ischemia
/
Stroke
/
Ischemic Stroke
Type of study:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Stroke Cerebrovasc Dis
Journal subject:
ANGIOLOGIA
/
CEREBRO
Year:
2023
Type:
Article
Affiliation country:
United States