Identification of Active Compounds against Melanoma Growth by Virtual Screening for Non-Classical Human DHFR Inhibitors.

Vásquez, Andrés Felipe; Gómez, Luis Alberto; González Barrios, Andrés; Riaño-Pachón, Diego M

Vásquez, Andrés Felipe; Gómez, Luis Alberto; González Barrios, Andrés; Riaño-Pachón, Diego M.

Affiliation

Vásquez AF; Grupo de Diseño de Productos y Procesos (GDPP), School of Chemical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Gómez LA; Naturalius SAS, Bogotá 110221, Colombia.
González Barrios A; Laboratorio de Fisiología Molecular, Instituto Nacional de Salud, Bogotá 111321, Colombia.
Riaño-Pachón DM; Department of Physiological Sciences, School of Medicine, Universidad Nacional de Colombia, Bogotá 11001, Colombia.

Int J Mol Sci ; 23(22)2022 Nov 11.

Article in En | MEDLINE | ID: mdl-36430425

Subject(s)

Antineoplastic Agents; Folic Acid Antagonists; Melanoma; Humans; Folic Acid Antagonists/pharmacology; Folic Acid Antagonists/chemistry; Tetrahydrofolate Dehydrogenase/metabolism; Antineoplastic Agents/pharmacology; Antineoplastic Agents/chemistry; Melanoma/drug therapy; Methotrexate/pharmacology

Key words

DHFR inhibitors; drug discovery; drug screening assays; melanoma; molecular docking simulations; pharmacophore modeling; virtual screening

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Folic Acid Antagonists / Melanoma / Antineoplastic Agents Type of study: Diagnostic_studies / Guideline / Screening_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2022 Type: Article Affiliation country: Colombia

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