Synthesis of C2-Carbonyl Indoles via Visible Light-Induced Oxidative Cleavage of an Aminomethylene Group.
J Org Chem
; 87(24): 16644-16654, 2022 12 16.
Article
in En
| MEDLINE
| ID: mdl-36445203
ABSTRACT
A strategy for photochemical oxidative cleavage of the aminomethylene group at the C2 position of indole was developed to synthesize C2-carbonyl indoles. The reaction was initiated by the photochemical oxidation of N1, followed by a water-assisted concerted H-shift by abstracting hydrogen from aminomethylene. Bromopyridine was discovered to play dual roles as an oxidant for the regeneration of photocatalysts and as an accelerant for the single-electron transfer process.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Indoles
/
Light
Language:
En
Journal:
J Org Chem
Year:
2022
Type:
Article
Affiliation country:
China