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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.
Belan, Ondrej; Sebald, Marie; Adamowicz, Marek; Anand, Roopesh; Vancevska, Aleksandra; Neves, Joana; Grinkevich, Vera; Hewitt, Graeme; Segura-Bayona, Sandra; Bellelli, Roberto; Robinson, Helen M R; Higgins, Geoff S; Smith, Graeme C M; West, Stephen C; Rueda, David S; Boulton, Simon J.
Affiliation
  • Belan O; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Sebald M; DNA Recombination and Repair Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Adamowicz M; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Anand R; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Vancevska A; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Neves J; Artios Pharma Ltd., B940 Babraham Research Campus, Cambridge CB22 3FH, UK.
  • Grinkevich V; Artios Pharma Ltd., B940 Babraham Research Campus, Cambridge CB22 3FH, UK.
  • Hewitt G; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Segura-Bayona S; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Bellelli R; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
  • Robinson HMR; Artios Pharma Ltd., B940 Babraham Research Campus, Cambridge CB22 3FH, UK.
  • Higgins GS; Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
  • Smith GCM; Artios Pharma Ltd., B940 Babraham Research Campus, Cambridge CB22 3FH, UK.
  • West SC; DNA Recombination and Repair Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Rueda DS; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London W12 0NN, UK; Single Molecule Imaging Group, MRC-London Institute of Medical Sciences, London W12 0NN, UK.
  • Boulton SJ; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Artios Pharma Ltd., B940 Babraham Research Campus, Cambridge CB22 3FH, UK. Electronic address: simon.boulton@crick.ac.uk.
Mol Cell ; 82(24): 4664-4680.e9, 2022 12 15.
Article in En | MEDLINE | ID: mdl-36455556
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Breaks, Double-Stranded / Neoplasms Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Breaks, Double-Stranded / Neoplasms Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: United kingdom