Lead/Drug Discovery from Natural Resources.
Molecules
; 27(23)2022 Nov 28.
Article
in En
| MEDLINE
| ID: mdl-36500375
ABSTRACT
Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022. Structurally typical marine bioactive products are also included. Molecular modeling, machine learning, bioinformatics and other computer-assisted techniques that are very important in narrowing down bioactive core structural scaffolds and helping to design new structures to fight against key disease-associated molecular targets based on available natural products are considered and briefly reviewed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biological Products
/
Anti-Infective Agents
/
Antineoplastic Agents
Language:
En
Journal:
Molecules
Journal subject:
BIOLOGIA
Year:
2022
Type:
Article
Affiliation country:
United States