Orally administered octacosanol improves liver insulin resistance in high-fat diet-fed mice through the reconstruction of the gut microbiota structure and inhibition of the TLR4/NF-&#954;B inflammatory pathway.

Ding, Yin-Yi; Fang, Yumeng; Pan, Yuxiang; Lan, Jinchi; Xu, Tao; Zhang, Wanyue; Mao, Huijuan; Gu, Zhenyu; Chen, Xi; Shen, Qing

Orally administered octacosanol improves liver insulin resistance in high-fat diet-fed mice through the reconstruction of the gut microbiota structure and inhibition of the TLR4/NF-κB inflammatory pathway.

Ding, Yin-Yi; Fang, Yumeng; Pan, Yuxiang; Lan, Jinchi; Xu, Tao; Zhang, Wanyue; Mao, Huijuan; Gu, Zhenyu; Chen, Xi; Shen, Qing.

Affiliation

Ding YY; Food Nutrition Science Center, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China. guzy84@163.com.
Fang Y; Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China.
Pan Y; Food Nutrition Science Center, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China. guzy84@163.com.
Lan J; Food Nutrition Science Center, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China. guzy84@163.com.
Xu T; Food Nutrition Science Center, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China. guzy84@163.com.
Zhang W; Huzhou Shengtao Biotechnology LLC, Huzhou, 313000, China.
Mao H; Food Nutrition Science Center, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China. guzy84@163.com.
Gu Z; Hangzhou Linping Hospital of Traditional Chinese Medicine, Linping, Zhejiang, 311106, China. maohuijuanky@163.com.
Chen X; Food Nutrition Science Center, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China. guzy84@163.com.
Shen Q; Center for General Practice Medicine, Department of General Practice Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 310014, China.

Food Funct ; 14(2): 769-786, 2023 Jan 23.

Article in En | MEDLINE | ID: mdl-36594412

Subject(s)

Gastrointestinal Microbiome; Insulin Resistance; Mice; Animals; NF-kappa B/metabolism; Diet, High-Fat; Toll-Like Receptor 4/metabolism; Liver/metabolism; Mice, Inbred C57BL

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Gastrointestinal Microbiome Limits: Animals Language: En Journal: Food Funct Year: 2023 Type: Article Affiliation country: China

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