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The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine.
Rajendran, Pradeep S; Hadaya, Joseph; Khalsa, Sahib S; Yu, Chuyue; Chang, Rui; Shivkumar, Kalyanam.
Affiliation
  • Rajendran PS; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: prajendran@partners.org.
  • Hadaya J; University of California, Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; UCLA Molecular, Cellular, and Integrative Physiology Program, Los Angeles, CA, USA.
  • Khalsa SS; Laureate Institute for Brain Research, Tulsa, Ok, USA; Oxley College of Health Sciences, University of Tulsa, Tulsa, Ok, USA.
  • Yu C; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
  • Chang R; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
  • Shivkumar K; University of California, Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; UCLA Molecular, Cellular, and Integrative Physiology Program, Los Angeles, CA, USA. Electronic address: kshivkumar
Semin Cell Dev Biol ; 156: 190-200, 2024 03 15.
Article in En | MEDLINE | ID: mdl-36641366
ABSTRACT
The parasympathetic nervous system via the vagus nerve exerts profound influence over the heart. Together with the sympathetic nervous system, the parasympathetic nervous system is responsible for fine-tuned regulation of all aspects of cardiovascular function, including heart rate, rhythm, contractility, and blood pressure. In this review, we highlight vagal efferent and afferent innervation of the heart, with a focus on insights from comparative biology and advances in understanding the molecular and genetic diversity of vagal neurons, as well as interoception, parasympathetic dysfunction in heart disease, and the therapeutic potential of targeting the parasympathetic nervous system in cardiovascular disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clinical Medicine / Heart Diseases Limits: Humans Language: En Journal: Semin Cell Dev Biol Journal subject: EMBRIOLOGIA Year: 2024 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clinical Medicine / Heart Diseases Limits: Humans Language: En Journal: Semin Cell Dev Biol Journal subject: EMBRIOLOGIA Year: 2024 Type: Article