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Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases.
Ramos-Llorca, Alba; Decraecker, Lisse; Cacheux, Valérie M Y; Zeiburlina, Irena; De Bruyn, Michelle; Battut, Louise; Moreno-Cinos, Carlos; Ceradini, Davide; Espinosa, Eric; Dietrich, Gilles; Berg, Maya; De Meester, Ingrid; Van Der Veken, Pieter; Boeckxstaens, Guy; Lambeir, Anne-Marie; Denadai-Souza, Alexandre; Augustyns, Koen.
Affiliation
  • Ramos-Llorca A; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
  • Decraecker L; Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
  • Cacheux VMY; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
  • Zeiburlina I; Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
  • De Bruyn M; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
  • Battut L; IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France.
  • Moreno-Cinos C; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
  • Ceradini D; Latvian Institute of Organic Synthesis, Riga, Latvia.
  • Espinosa E; IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France.
  • Dietrich G; IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France.
  • Berg M; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
  • De Meester I; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
  • Van Der Veken P; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
  • Boeckxstaens G; Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
  • Lambeir AM; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
  • Denadai-Souza A; Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
  • Augustyns K; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Front Chem ; 10: 1089959, 2022.
Article in En | MEDLINE | ID: mdl-36688031
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Chem Year: 2022 Type: Article Affiliation country: Belgium
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Chem Year: 2022 Type: Article Affiliation country: Belgium