Recent developments on natural polysaccharides as potential anti-gastric cancer substance: Structural feature and bioactivity.

ABSTRACT

Gastric cancer (GC) is being a serious threat to human health. Seeking safer and more effective ingredients for anti-GC is of significance. Increasing natural polysaccharides (NPs) have been demonstrated to possess anti-GC activity. However, the information on anti-GC NPs is scattered. For well-understanding the potential of NPs as anti-GC substances, the recent developments on structure, bioactivity and mechanism of anti-GC NPs were comprehensively reviewed in this article. Meanwhile, the structure-activity relationship was discussed. Recent studies indicated that anti-GC NPs could be mainly divided into glucan and heteropolysaccharide, whose structures affected by sources and protocols of extraction and purification. NPs exhibited anti-GC activities in cell and animal experiments as well as clinical trials, and the mechanisms might be anti-proliferation, inducing apoptosis, anti-metastasis and anti-invasion, inducing autophagy, boosting immunity, anti-angiogenesis, reducing drug resistance, anti-angiogenesis, improving antioxidant level and changing metabolites. Moreover, structural features included molecular weight, functional groups, uronic acid and monosaccharide composition, glycosidic linkage type, and degree of branching and conformation might influence the activities. Otherwise, modifications could enhance the anti-GC activity of NPs, and anti-GC NPs could be combinedly used with chemotherapeutic drugs. This review supports the applications of NPs in anti-GC and provides theoretical basis for future study.