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Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads.
Wang, Jingyao; Zhou, Shaoqing; Cheng, Yan; Cheng, Lin; Qin, Ying; Zhang, Zhenfeng; Bi, Aiwei; Xiang, Huaijiang; He, Xinheng; Tian, Xiaoxu; Liu, Wenbin; Zhang, Jian; Peng, Chao; Zhu, Zhengjiang; Huang, Min; Li, Ying; Zhuang, Guanglei; Tan, Li.
Affiliation
  • Wang J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
  • Zhou S; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Cheng Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
  • Cheng L; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Qin Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
  • Zhang Z; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
  • Bi A; Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
  • Xiang H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
  • He X; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Tian X; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
  • Liu W; Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
  • Zhang J; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Peng C; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Zhu Z; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
  • Huang M; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Li Y; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
  • Zhuang G; National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China.
  • Tan L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
J Med Chem ; 66(4): 2608-2621, 2023 02 23.
Article in En | MEDLINE | ID: mdl-36723914
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Kinase / Drug Discovery Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Kinase / Drug Discovery Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: China