COVID-19 VACCINE-INDUCED ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY: CASE REPORTS.
Retin Cases Brief Rep
; 18(1): 66-70, 2024 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-36731098
ABSTRACT
BACKGROUND:
Acute exudative polymorphous vitelliform maculopathy is a presumed retinal pigment epithelium abnormality that has been reported in patients with neoplasms and under certain classes of drugs. The pathophysiology remains unclear, despite the typical clinical features.PURPOSE:
To report two cases of acute exudative polymorphous vitelliform maculopathy occurring after vaccination with a COVID-19 vaccine. CASE REPORTS Two adult patients presented with visual disturbance after inoculation with a COVID-19 vaccine. The patients were otherwise healthy and have no family history of retinal dystrophies. Both cases exhibited the following features on multimodal imaging multifocal hyporeflective lesions involving the macula, elongated photoreceptors, accumulated vitelliform material exhibiting autofluorescence, and lack of fluorescein dye leakage. Evidence of retinal pigment epithelium dysfunction was confirmed by electrooculography.CONCLUSION:
Two cases of acute exudative polymorphous vitelliform maculopathy occurring after COVID-19 vaccination were reported. A relationship between the vaccine and the retinal pigment epithelial abnormality development that led to acute exudative polymorphous vitelliform maculopathy was postulate, possibly through autoantibodies against the severe acute respiratory syndrome coronavirus 2 virus structural surface glycoprotein antigens that cross react with the normal retinal pigment epithelial cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitelliform Macular Dystrophy
/
Retinal Dystrophies
/
COVID-19 Vaccines
/
COVID-19
/
Macular Degeneration
Limits:
Adult
/
Humans
Language:
En
Journal:
Retin Cases Brief Rep
/
Retin. cases brief rep. (Online)
/
Retinal cases & brief reports (Online)
Year:
2024
Type:
Article
Affiliation country:
Egypt