Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus.

Boutros, Sydney Weber; Zimmerman, Benjamin; Nagy, Sydney C; Unni, Vivek K; Raber, Jacob

Boutros, Sydney Weber; Zimmerman, Benjamin; Nagy, Sydney C; Unni, Vivek K; Raber, Jacob.

Affiliation

Boutros SW; Department of Behavioral Neuroscience, OHSU, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.
Zimmerman B; Department of Psychological Sciences, Boise State University, 2133 W Cesar Chavez Ln, Boise, ID, 83725, USA.
Nagy SC; Department of Behavioral Neuroscience, OHSU, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.
Unni VK; Advanced Imaging Research Center, OHSU, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.
Raber J; Helfgott Research Institute, NUNM, 2201 SW First Avenue, Portland, OR, 97201, USA.

Mol Psychiatry ; 28(8): 3343-3354, 2023 Aug.

Article in En | MEDLINE | ID: mdl-36732588

Subject(s)

Alzheimer Disease; Apolipoproteins E; Fear; Animals; Female; Humans; Male; Mice; Middle Aged; Alzheimer Disease/genetics; Alzheimer Disease/metabolism; Apolipoprotein E2/genetics; Apolipoprotein E3/genetics; Apolipoprotein E3/metabolism; Apolipoprotein E4/genetics; Apolipoproteins E/genetics; DNA Damage; Extinction, Psychological; Hippocampus/metabolism; Mice, Transgenic; Protein Isoforms/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Fear / Alzheimer Disease Type of study: Risk_factors_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2023 Type: Article Affiliation country: United States

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