Crystallization of VHL-based PROTAC-induced ternary complexes.

Wijaya, Andre J; Farnaby, William; Ciulli, Alessio

Wijaya, Andre J; Farnaby, William; Ciulli, Alessio.

Affiliation

Wijaya AJ; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
Farnaby W; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
Ciulli A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom. Electronic address: a.ciulli@dundee.ac.uk.

Methods Enzymol ; 681: 241-263, 2023.

Article in En | MEDLINE | ID: mdl-36764760

Subject(s)

Proteolysis Targeting Chimera; Ubiquitin-Protein Ligases; Crystallization; Proteolysis; Ubiquitin-Protein Ligases/metabolism

Key words

Cereblon; Crystallization; E3 ligase; PROTAC; Structural biology; VHL; X-ray crystallography

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Proteolysis Targeting Chimera Language: En Journal: Methods Enzymol Year: 2023 Type: Article Affiliation country: United kingdom

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