Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation.

Hou, Liyan; Liu, Jianing; Sun, Fuqiang; Huang, Ruixue; Chang, Rui; Ruan, Zhengzheng; Wang, Ying; Zhao, Jie; Wang, Qingshan

Hou, Liyan; Liu, Jianing; Sun, Fuqiang; Huang, Ruixue; Chang, Rui; Ruan, Zhengzheng; Wang, Ying; Zhao, Jie; Wang, Qingshan.

Affiliation

Hou L; Dalian Medical University Library, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian, 116044, China.
Liu J; National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, China.
Sun F; School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian, 116044, China.
Huang R; School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian, 116044, China.
Chang R; School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian, 116044, China.
Ruan Z; School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian, 116044, China.
Wang Y; School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian, 116044, China.
Zhao J; School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian, 116044, China.
Wang Q; National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, China. zhaoj@dmu.edu.cn.

J Neuroinflammation ; 20(1): 42, 2023 Feb 18.

Article in En | MEDLINE | ID: mdl-36804009

Subject(s)

Maneb; Paraquat; Parkinson Disease; Animals; Mice; alpha-Synuclein/metabolism; Disease Models, Animal; Dopaminergic Neurons; Inflammasomes/metabolism; Integrins/metabolism; Macrophages/metabolism; Maneb/toxicity; Memory Disorders/metabolism; Microglia/metabolism; NADPH Oxidases/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Paraquat/toxicity; Parkinson Disease/pathology; Macrophage-1 Antigen

Key words

Integrin; Learning and memory deficits; Microglial activation; NADPH oxidase; NLRP3 inflammasome; Parkinson's disease; Pesticide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paraquat / Parkinson Disease / Maneb Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2023 Type: Article Affiliation country: China

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