Spinal Interneurons: Diversity and Connectivity in Motor Control.
Annu Rev Neurosci
; 46: 79-99, 2023 07 10.
Article
in En
| MEDLINE
| ID: mdl-36854318
ABSTRACT
The spinal cord is home to the intrinsic networks for locomotion. An animal in which the spinal cord has been fully severed from the brain can still produce rhythmic, patterned locomotor movements as long as some excitatory drive is provided, such as physical, pharmacological, or electrical stimuli. Yet it remains a challenge to define the underlying circuitry that produces these movements because the spinal cord contains a wide variety of neuron classes whose patterns of interconnectivity are still poorly understood. Computational models of locomotion accordingly rely on untested assumptions about spinal neuron network element identity and connectivity. In this review, we consider the classes of spinal neurons, their interconnectivity, and the significance of their circuit connections along the long axis of the spinal cord. We suggest several lines of analysis to move toward a definitive understanding of the spinal network.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord
/
Interneurons
Limits:
Animals
Language:
En
Journal:
Annu Rev Neurosci
Year:
2023
Type:
Article