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SCOPE: Surveillance of COVID-19 in pregnancy- results of a multicentric ambispective case-control study on clinical presentation and maternal outcomes in India between April to November 2020.
Kumar, Sunesh; Bhatla, Neerja; Sharma, K Aparna; Agarwal, Ramesh; Verma, Ankit; Perumal, Vanamail; Shiv Kumar, Poonam; Garg, B S; Goudar, Shivaprasad S; Pujar, Yeshita V; Kavi, Avinash; Suri, Vanita; Joshi, Bharti; Rathore, Asmita; Gupta, Madhavi M; Kumar, Ajay; Puri, Manju; Meena, Deepika; Nangia, Sushma; Arora, Renu; Bachani, Sumitra; Anand, Pratima; Seth, Shikha; Gupta, Rakesh; Sehgal, Rohini; Rana, Anubhuti; Kumari, Archana; P, Shainy; Donimath, Kasturi; Gowder, Guruprasad; Kedar, Lakshmi; Kar, Tushar; Mishra, Sujata; Joshi, Chinmayi; Kabade, Yogendra; Kamatar, Saroja; Nanda, Saumya; Mohapatra, Vandana; Vellanki, Janki; Agarwal, Sarita; Borkar, Aparna Wahane; Kumar, Aruna; Sultan, Shabana; Gangane, Neha; Chaudhary, Pushpa; Jayathilaka, Anoma; Raina, Neena; Karna, Priya.
Affiliation
  • Kumar S; All India Institute of Medical Sciences, New Delhi, India.
  • Bhatla N; All India Institute of Medical Sciences, New Delhi, India.
  • Sharma KA; All India Institute of Medical Sciences, New Delhi, India.
  • Agarwal R; All India Institute of Medical Sciences, New Delhi, India.
  • Verma A; All India Institute of Medical Sciences, New Delhi, India.
  • Perumal V; All India Institute of Medical Sciences, New Delhi, India.
  • Shiv Kumar P; Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India.
  • Garg BS; Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India.
  • Goudar SS; Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India.
  • Pujar YV; Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India.
  • Kavi A; Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India.
  • Suri V; Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Joshi B; Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Rathore A; Maulana Azad Medical College, New Delhi, India.
  • Gupta MM; Maulana Azad Medical College, New Delhi, India.
  • Kumar A; Maulana Azad Medical College, New Delhi, India.
  • Puri M; Lady Hardinge Medical Delhi, New Delhi, India.
  • Meena D; Lady Hardinge Medical Delhi, New Delhi, India.
  • Nangia S; Lady Hardinge Medical Delhi, New Delhi, India.
  • Arora R; Vardhaman Medical College and Safdarjung Hospital, New Delhi, India.
  • Bachani S; Vardhaman Medical College and Safdarjung Hospital, New Delhi, India.
  • Anand P; Vardhaman Medical College and Safdarjung Hospital, New Delhi, India.
  • Seth S; Government Institute of Medical Sciences, Noida, Uttar Pradesh, India.
  • Gupta R; Government Institute of Medical Sciences, Noida, Uttar Pradesh, India.
  • Sehgal R; All India Institute of Medical Sciences, New Delhi, India.
  • Rana A; All India Institute of Medical Sciences, New Delhi, India.
  • Kumari A; All India Institute of Medical Sciences, New Delhi, India.
  • P S; All India Institute of Medical Sciences, New Delhi, India.
  • Donimath K; Karnataka Institute of Medical Sciences, Hubli, Karnataka.
  • Gowder G; J J M Medical College, Davanagere, Karnataka.
  • Kedar L; Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India.
  • Kar T; S C B Medical College, Cuttack, Odisha, India.
  • Mishra S; Fakir Mohan Medical College, Balasore, Odisha, India.
  • Joshi C; Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India.
  • Kabade Y; Karnataka Institute of Medical Sciences, Hubli, Karnataka.
  • Kamatar S; J J M Medical College, Davanagere, Karnataka.
  • Nanda S; S C B Medical College, Cuttack, Odisha, India.
  • Mohapatra V; Gandhi Medical College, Hyderabad, Telagana, India.
  • Vellanki J; Gandhi Medical College, Hyderabad, Telagana, India.
  • Agarwal S; AIIMS, Raipur, Chhatisgarh, India.
  • Borkar AW; Government Medical College, Akola, Maharashtra, India.
  • Kumar A; Government Medical College, Bhopal, Madhya Pradesh, India.
  • Sultan S; Government Medical College, Bhopal, Madhya Pradesh, India.
  • Gangane N; Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India.
  • Chaudhary P; WHO, New Delhi, India.
  • Jayathilaka A; WHO, SEAR, New Delhi, India.
  • Raina N; WHO, SEAR, New Delhi, India.
  • Karna P; WHO, New Delhi, India.
PLoS One ; 18(3): e0272381, 2023.
Article in En | MEDLINE | ID: mdl-36877672
OBJECTIVE: To determine the clinical manifestations, risk factors, treatment modalities and maternal outcomes in pregnant women with lab-confirmed COVID-19 and compare it with COVID-19 negative pregnant women in same age group. DESIGN: Multicentric case-control study. DATA SOURCES: Ambispective primary data collection through paper-based forms from 20 tertiary care centres across India between April and November 2020. STUDY POPULATION: All pregnant women reporting to the centres with a lab-confirmed COVID-19 positive result matched with controls. DATA QUALITY: Dedicated research officers extracted hospital records, using modified WHO Case Record Forms (CRF) and verified for completeness and accuracy. STATISTICAL ANALYSIS: Data converted to excel files and statistical analyses done using STATA 16 (StataCorp, TX, USA). Odds ratios (ORs) with 95% confidence intervals (CI) estimated using unconditional logistic regression. RESULTS: A total of 76,264 women delivered across 20 centres during the study period. Data of 3723 COVID positive pregnant women and 3744 age-matched controls was analyzed. Of the positive cases 56·9% were asymptomatic. Antenatal complications like preeclampsia and abruptio placentae were seen more among the cases. Induction and caesarean delivery rates were also higher among Covid positive women. Pre-existing maternal co-morbidities increased need for supportive care. There were 34 maternal deaths out of the 3723(0.9%) positive mothers, while covid negative deaths reported from all the centres were 449 of 72,541 (0·6%). CONCLUSION: Covid-19 infection predisposed to adverse maternal outcomes in a large cohort of Covid positive pregnant women as compared to the negative controls.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Abruptio Placentae / COVID-19 Type of study: Clinical_trials / Observational_studies / Risk_factors_studies / Screening_studies Limits: Female / Humans / Pregnancy Country/Region as subject: Asia Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2023 Type: Article Affiliation country: India

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Abruptio Placentae / COVID-19 Type of study: Clinical_trials / Observational_studies / Risk_factors_studies / Screening_studies Limits: Female / Humans / Pregnancy Country/Region as subject: Asia Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2023 Type: Article Affiliation country: India