Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma.
J Appl Clin Med Phys
; 24(7): e13954, 2023 Jul.
Article
in En
| MEDLINE
| ID: mdl-36913484
ABSTRACT
PURPOSE:
We developed and tested a novel method of creating intensity modulated proton arc therapy (IMPAT) plans that uses computing resources similar to those for regular intensity-modulated proton therapy (IMPT) plans and may offer a dosimetric benefit for patients with ependymoma or similar tumor geometries.METHODS:
Our IMPAT planning method consists of a geometry-based energy selection step with major scanning spot contributions as inputs computed using ray-tracing and single-Gaussian approximation of lateral spot profiles. Based on the geometric relation of scanning spots and dose voxels, our energy selection module selects a minimum set of energy layers at each gantry angle such that each target voxel is covered by sufficient scanning spots as specified by the planner, with dose contributions above the specified threshold. Finally, IMPAT plans are generated by robustly optimizing scanning spots of the selected energy layers using a commercial proton treatment planning system (TPS). The IMPAT plan quality was assessed for four ependymoma patients. Reference three-field IMPT plans were created with similar planning objective functions and compared with the IMPAT plans.RESULTS:
In all plans, the prescribed dose covered 95% of the clinical target volume (CTV) while maintaining similar maximum doses for the brainstem. While IMPAT and IMPT achieved comparable plan robustness, the IMPAT plans achieved better homogeneity and conformity than the IMPT plans. The IMPAT plans also exhibited higher relative biological effectiveness (RBE) enhancement than did the corresponding reference IMPT plans for the CTV in all four patients and brainstem in three of them.CONCLUSIONS:
The proposed method demonstrated potential as an efficient technique for IMPAT planning and may offer a dosimetric benefit for patients with ependymoma or tumors in close proximity to critical organs. IMPAT plans created using this method had elevated RBE enhancement associated with increased linear energy transfer (LET) in both targets and abutting critical organs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ependymoma
/
Radiotherapy, Intensity-Modulated
/
Proton Therapy
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
J Appl Clin Med Phys
Journal subject:
BIOFISICA
Year:
2023
Type:
Article
Affiliation country:
United States