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CYP11B2 inhibitor dexfadrostat phosphate suppresses the aldosterone-to-renin ratio, an indicator of sodium retention, in healthy volunteers.
Mulatero, Paolo; Groessl, Michael; Vogt, Bruno; Schumacher, Christoph; Steele, Ronald Edward; Brooks, Ashley; Hossack, Stuart; Brunner, Hans-Rudolf.
Affiliation
  • Mulatero P; Division of Internal Medicine and Hypertension, University of Torino, Torino, Italy.
  • Groessl M; Clinic for Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Vogt B; Clinic for Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Schumacher C; DAMIAN Pharma AG, Walchwil, Switzerland.
  • Steele RE; DAMIAN Pharma AG, Walchwil, Switzerland.
  • Brooks A; Covance Clinical Research, Leeds, UK.
  • Hossack S; Covance Clinical Research, Leeds, UK.
  • Brunner HR; Faculty of Biology and Medicine, Lausanne University, Lausanne, Switzerland.
Br J Clin Pharmacol ; 89(8): 2483-2496, 2023 08.
Article in En | MEDLINE | ID: mdl-36914591
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aldosterone / Hypertension Type of study: Clinical_trials Limits: Humans Language: En Journal: Br J Clin Pharmacol Year: 2023 Type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aldosterone / Hypertension Type of study: Clinical_trials Limits: Humans Language: En Journal: Br J Clin Pharmacol Year: 2023 Type: Article Affiliation country: Italy