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A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.
Alegre-Martí, Andrea; Jiménez-Panizo, Alba; Martínez-Tébar, Adrián; Poulard, Coralie; Peralta-Moreno, M Núria; Abella, Montserrat; Antón, Rosa; Chiñas, Marcos; Eckhard, Ulrich; Piulats, Josep M; Rojas, Ana M; Fernández-Recio, Juan; Rubio-Martínez, Jaime; Le Romancer, Muriel; Aytes, Álvaro; Fuentes-Prior, Pablo; Estébanez-Perpiñá, Eva.
Affiliation
  • Alegre-Martí A; Structural Biology of Nuclear Receptors, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.
  • Jiménez-Panizo A; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.
  • Martínez-Tébar A; Structural Biology of Nuclear Receptors, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.
  • Poulard C; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.
  • Peralta-Moreno MN; Programs of Molecular Mechanisms and Experimental Therapeutics in Oncology (ONCOBell) and Cancer Therapeutics Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, 08908 Barcelona, Spain.
  • Abella M; Cancer Research Center of Lyon, CNRS UMR5286, Inserm U1502, University of Lyon, 69000 Lyon, France.
  • Antón R; Department of Materials Science and Physical Chemistry, Faculty of Chemistry and Institut de Recerca en Química Teorica i Computacional (IQTCUB), 08028 Barcelona, Spain.
  • Chiñas M; Structural Biology of Nuclear Receptors, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.
  • Eckhard U; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.
  • Piulats JM; Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
  • Rojas AM; Programs of Molecular Mechanisms and Experimental Therapeutics in Oncology (ONCOBell) and Cancer Therapeutics Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, 08908 Barcelona, Spain.
  • Fernández-Recio J; Universidad Nacional Autónoma de México, Centro de Ciencias Genómicas, Cuernavaca, 61740 Morelos, Mexico.
  • Rubio-Martínez J; Department of Structural and Molecular Biology, Molecular Biology Institute of Barcelona (IBMB-CSIC), 08028 Barcelona, Spain.
  • Le Romancer M; Programs of Molecular Mechanisms and Experimental Therapeutics in Oncology (ONCOBell) and Cancer Therapeutics Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, 08908 Barcelona, Spain.
  • Aytes Á; Computational Biology and Bioinformatics, Andalusian Center for Developmental Biology (CABD-CSIC), 41013 Sevilla, Spain.
  • Fuentes-Prior P; Instituto de Ciencias de la Vid y del Vino (ICVV-CSIC), CSIC-UR-Gobierno de La Rioja, 26007 Logroño, Spain.
  • Estébanez-Perpiñá E; Department of Materials Science and Physical Chemistry, Faculty of Chemistry and Institut de Recerca en Química Teorica i Computacional (IQTCUB), 08028 Barcelona, Spain.
Sci Adv ; 9(11): eade2175, 2023 03 17.
Article in En | MEDLINE | ID: mdl-36921044
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Receptors, Androgen Limits: Humans / Male Language: En Journal: Sci Adv Year: 2023 Type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Receptors, Androgen Limits: Humans / Male Language: En Journal: Sci Adv Year: 2023 Type: Article Affiliation country: Spain