Extracellular vesicles from hyperammonemic rats induce neuroinflammation in hippocampus and impair cognition in control rats.

Izquierdo-Altarejos, Paula; Martínez-García, Mar; Felipo, Vicente

Izquierdo-Altarejos, Paula; Martínez-García, Mar; Felipo, Vicente.

Affiliation

Izquierdo-Altarejos P; Laboratory of Neurobiology, Centro de Investigacion Príncipe Felipe, Eduardo Primo-Yufera 3, 46012, Valencia, Spain.
Martínez-García M; Laboratory of Neurobiology, Centro de Investigacion Príncipe Felipe, Eduardo Primo-Yufera 3, 46012, Valencia, Spain.
Felipo V; Laboratory of Neurobiology, Centro de Investigacion Príncipe Felipe, Eduardo Primo-Yufera 3, 46012, Valencia, Spain. vfelipo@cipf.es.

Cell Mol Life Sci ; 80(4): 90, 2023 Mar 15.

Article in En | MEDLINE | ID: mdl-36922433

Subject(s)

Extracellular Vesicles; Hepatic Encephalopathy; Hyperammonemia; Rats; Animals; Rats, Wistar; Tumor Necrosis Factor-alpha/metabolism; Receptors, Tumor Necrosis Factor, Type I/metabolism; Receptors, Tumor Necrosis Factor, Type I/pharmacology; Neuroinflammatory Diseases; NF-KappaB Inhibitor alpha/metabolism; NF-KappaB Inhibitor alpha/pharmacology; Hepatic Encephalopathy/metabolism; Hepatic Encephalopathy/pathology; Hyperammonemia/metabolism; Hyperammonemia/pathology; Inflammation/metabolism; Cognition; Extracellular Vesicles/metabolism; Hippocampus/metabolism

Key words

AMPA receptors; Astrocytes activation; Hepatic encephalopathy; Microglia activation; TNFR1; TNFα

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatic Encephalopathy / Hyperammonemia / Extracellular Vesicles Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: Spain

Fulltext

XML

PubMed Links

Search on Google