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A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.
El Zawily, Amr; Vizeacoumar, Frederick S; Dahiya, Renuka; Banerjee, Sara L; Bhanumathy, Kalpana K; Elhasasna, Hussain; Hanover, Glinton; Sharpe, Jessica C; Sanchez, Malkon G; Greidanus, Paul; Stacey, R Greg; Moon, Kyung-Mee; Alexandrov, Ilya; Himanen, Juha P; Nikolov, Dimitar B; Fonge, Humphrey; White, Aaron P; Foster, Leonard J; Wang, Bingcheng; Toosi, Behzad M; Bisson, Nicolas; Mirzabekov, Tajib A; Vizeacoumar, Franco J; Freywald, Andrew.
Affiliation
  • El Zawily A; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Vizeacoumar FS; Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa.
  • Dahiya R; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Banerjee SL; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Bhanumathy KK; Department of Molecular Biology, Medical Biochemistry and Pathology, PROTEO and Centre de recherche du Centre Hospitalier Universitaire (CHU) de Quebec-Université Laval, Division Oncologie, Québec, Canada.
  • Elhasasna H; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Hanover G; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Sharpe JC; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Sanchez MG; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Health Sciences, Saskatoon, Saskatchewan, Canada.
  • Greidanus P; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
  • Stacey RG; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Moon KM; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Health Sciences, Saskatoon, Saskatchewan, Canada.
  • Alexandrov I; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Himanen JP; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Health Sciences, Saskatoon, Saskatchewan, Canada.
  • Nikolov DB; Michael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Fonge H; Michael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
  • White AP; Biomirex Inc., Natick, Massachusetts.
  • Foster LJ; Department of Biochemistry, University of Turku, Turku, Finland.
  • Wang B; Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Toosi BM; Department of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
  • Bisson N; Department of Medical Imaging, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
  • Mirzabekov TA; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Health Sciences, Saskatoon, Saskatchewan, Canada.
  • Vizeacoumar FJ; Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
  • Freywald A; Michael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Clin Cancer Res ; 29(14): 2686-2701, 2023 07 14.
Article in En | MEDLINE | ID: mdl-36976175
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Bispecific / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2023 Type: Article Affiliation country: Canada
Fulltext
Print
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PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Bispecific / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2023 Type: Article Affiliation country: Canada