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TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models.
Meyran, Deborah; Zhu, Joe Jiang; Butler, Jeanne; Tantalo, Daniela; MacDonald, Sean; Nguyen, Thu Ngoc; Wang, Minyu; Thio, Niko; D'Souza, Criselle; Qin, Vicky Mengfei; Slaney, Clare; Harrison, Aaron; Sek, Kevin; Petrone, Pasquale; Thia, Kevin; Giuffrida, Lauren; Scott, Andrew M; Terry, Rachael L; Tran, Ben; Desai, Jayesh; Prince, H Miles; Harrison, Simon J; Beavis, Paul A; Kershaw, Michael H; Solomon, Ben; Ekert, Paul G; Trapani, Joseph A; Darcy, Phillip K; Neeson, Paul J.
Affiliation
  • Meyran D; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Zhu JJ; Université de Paris, Inserm, U976 HIPI Unit, Institut de Recherche Saint-Louis, Paris F-75010, France.
  • Butler J; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.
  • Tantalo D; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • MacDonald S; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.
  • Nguyen TN; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Wang M; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Thio N; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • D'Souza C; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Qin VM; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Slaney C; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.
  • Harrison A; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Sek K; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Petrone P; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.
  • Thia K; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Giuffrida L; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.
  • Scott AM; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Terry RL; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.
  • Tran B; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Desai J; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Prince HM; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.
  • Harrison SJ; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Beavis PA; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Kershaw MH; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.
  • Solomon B; Tumor Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Austin Health, Heidelberg, VIC 3084, Australia.
  • Ekert PG; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.
  • Trapani JA; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 1466, Australia.
  • Darcy PK; Division of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
  • Neeson PJ; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne 3010, Australia.
Sci Transl Med ; 15(690): eabk1900, 2023 04 05.
Article in En | MEDLINE | ID: mdl-37018415
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy, Adoptive / Neoplasms Type of study: Clinical_trials / Guideline Limits: Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2023 Type: Article Affiliation country: Australia
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy, Adoptive / Neoplasms Type of study: Clinical_trials / Guideline Limits: Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2023 Type: Article Affiliation country: Australia