Antitumor activity and mechanisms of dual EGFR/DNA-targeting strategy for the treatment of lung cancer with EGFR<sup>L858R/T790M</sup> mutation.

Dai, Lumei; Qin, Feng; Xie, Yuying; Zhang, Bin; Zhang, Zhijie; Liang, Sijia; Chen, Fujia; Huang, Xiaochao; Wang, Hengshan

Antitumor activity and mechanisms of dual EGFR/DNA-targeting strategy for the treatment of lung cancer with EGFR^L858R/T790M mutation.

Dai, Lumei; Qin, Feng; Xie, Yuying; Zhang, Bin; Zhang, Zhijie; Liang, Sijia; Chen, Fujia; Huang, Xiaochao; Wang, Hengshan.

Affiliation

Dai L; School of Biological and Food Engineering, Huanghuai University, Zhumadian 463000, China.
Qin F; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China.
Xie Y; School of Biological and Food Engineering, Huanghuai University, Zhumadian 463000, China.
Zhang B; School of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China. Electronic address: zhbin308@163.com.
Zhang Z; School of Biological and Food Engineering, Huanghuai University, Zhumadian 463000, China.
Liang S; School of Biological and Food Engineering, Huanghuai University, Zhumadian 463000, China.
Chen F; School of Biological and Food Engineering, Huanghuai University, Zhumadian 463000, China.
Huang X; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technolog
Wang H; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China. Electronic address: whengshan@163.com.

Bioorg Chem ; 135: 106510, 2023 06.

Article in En | MEDLINE | ID: mdl-37018899

Subject(s)

Antineoplastic Agents; Lung Neoplasms; Humans; Lung Neoplasms/drug therapy; ErbB Receptors; Gefitinib/pharmacology; Molecular Docking Simulation; Cell Proliferation; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Protein Kinase Inhibitors/chemistry; Cell Line, Tumor; Mutation; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Antineoplastic Agents/chemistry; Drug Resistance, Neoplasm

Key words

Anticancer; DNA damage; EGFR inhibitors; Nitrogen mustard; Quinazoline

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lung Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2023 Type: Article Affiliation country: China

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