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Meta-analysis reveals a reduced surface area of the amygdala in individuals with attention deficit/hyperactivity disorder.
Chen, Meng-Hsiang; Lin, Hsiu-Man; Sue, Yu-Ru; Yu, Yun-Chen; Yeh, Pin-Yang.
Affiliation
  • Chen MH; Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
  • Lin HM; College of Medicine, Chang Gung University, Kaohsiung, Taiwan.
  • Sue YR; Division of Child and Adolescent Psychiatry & Division of Developmental and Behavioral Pediatrics, China Medical University Children's Hospital, Taichung, Taiwan.
  • Yu YC; Department of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan.
  • Yeh PY; Department of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan.
Psychophysiology ; 60(9): e14308, 2023 09.
Article in En | MEDLINE | ID: mdl-37042481
Despite the reported lack of structural alterations in the amygdala of individuals with attention deficit/hyperactivity disorder (ADHD) in previous meta-analyses, subsequent observational studies produced conflicting results. Through incorporating the updated data from observational studies on structural features of the amygdala in ADHD, the primary goal of this study was to examine the anatomical differences in amygdala between subjects with ADHD and their neurotypical controls. Using the appropriate keyword strings, we searched the PubMed, Embase, and Web of Science databases for English articles from inception to February 2022. Eligibility criteria included observational studies comparing the structure of the amygdala between ADHD subjects and their comparators using magnetic resonance imaging (MRI). Subgroup analyses were conducted focusing on the amygdala side, as well as the use of different scanners and approach to segmentation. The effects of other continuous variables, such as age, intelligence quotient, and male percentage, on amygdala size were also investigated. Of the 5703 participants in 16 eligible studies, 2928 were diagnosed with ADHD. Compared with neurotypical controls, subjects with ADHD had a smaller amygdala surface area (particularly in the left hemisphere) but without a significant difference in volume between the two groups. Subgroup analysis of MRI scanners and different approaches to segmentation showed no statistically significant difference. There was no significant correlation between continuous variables and amygdala size. Our results showed consistent surface morphological alterations of the amygdala, in particular on the left side, in subjects with ADHD. However, the preliminary findings based on the limited data available for analysis warrant future studies for verification.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Attention Deficit Disorder with Hyperactivity Type of study: Observational_studies / Systematic_reviews Limits: Female / Humans / Male Language: En Journal: Psychophysiology Year: 2023 Type: Article Affiliation country: Taiwan

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Attention Deficit Disorder with Hyperactivity Type of study: Observational_studies / Systematic_reviews Limits: Female / Humans / Male Language: En Journal: Psychophysiology Year: 2023 Type: Article Affiliation country: Taiwan