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FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Wieder, Nicolas; Fried, Juliana Coraor; Kim, Choah; Sidhom, Eriene-Heidi; Brown, Matthew R; Marshall, Jamie L; Arevalo, Carlos; Dvela-Levitt, Moran; Kost-Alimova, Maria; Sieber, Jonas; Gabriel, Katlyn R; Pacheco, Julian; Clish, Clary; Abbasi, Hamdah Shafqat; Singh, Shantanu; Rutter, Justine C; Therrien, Martine; Yoon, Haejin; Lai, Zon Weng; Baublis, Aaron; Subramanian, Renuka; Devkota, Ranjan; Small, Jonnell; Sreekanth, Vedagopuram; Han, Myeonghoon; Lim, Donghyun; Carpenter, Anne E; Flannick, Jason; Finucane, Hilary; Haigis, Marcia C; Claussnitzer, Melina; Sheu, Eric; Stevens, Beth; Wagner, Bridget K; Choudhary, Amit; Shaw, Jillian L; Pablo, Juan Lorenzo; Greka, Anna.
Affiliation
  • Wieder N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Neurology with Experimental Neurology and Berlin Institute of Health, Charité, 10117 Berlin, Germany
  • Fried JC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Kim C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Sidhom EH; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Brown MR; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Marshall JL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Arevalo C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Dvela-Levitt M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
  • Kost-Alimova M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Sieber J; Department of Endocrinology, Metabolism and Cardiovascular Systems, University of Fribourg, Fribourg, Switzerland.
  • Gabriel KR; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Pacheco J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Clish C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Abbasi HS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Singh S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Rutter JC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Therrien M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Yoon H; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center for Cancer Research at Harvard, Boston, MA 02115, USA.
  • Lai ZW; Harvard Chan Advanced Multiomics Platform, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Baublis A; Harvard Chan Advanced Multiomics Platform, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Subramanian R; Laboratory for Surgical and Metabolic Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Devkota R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Small J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Sreekanth V; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Han M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Lim D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Carpenter AE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Flannick J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA.
  • Finucane H; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Mass General Hospital, Boston, MA 02114, USA.
  • Haigis MC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center for Cancer Research at Harvard, Boston, MA 02115, USA.
  • Claussnitzer M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Sheu E; Laboratory for Surgical and Metabolic Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Stevens B; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA.
  • Wagner BK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Choudhary A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA
  • Shaw JL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Pablo JL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Greka A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: agreka@bwh.harvard.edu.
Cell Metab ; 35(5): 887-905.e11, 2023 05 02.
Article in En | MEDLINE | ID: mdl-37075753
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Fatty Acids, Nonesterified Limits: Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2023 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Fatty Acids, Nonesterified Limits: Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2023 Type: Article Affiliation country: Germany