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Oncogenic CDK13 mutations impede nuclear RNA surveillance.
Insco, Megan L; Abraham, Brian J; Dubbury, Sara J; Kaltheuner, Ines H; Dust, Sofia; Wu, Constance; Chen, Kevin Y; Liu, David; Bellaousov, Stanislav; Cox, Anna M; Martin, Benjamin J E; Zhang, Tongwu; Ludwig, Calvin G; Fabo, Tania; Modhurima, Rodsy; Esgdaille, Dakarai E; Henriques, Telmo; Brown, Kevin M; Chanock, Stephen J; Geyer, Matthias; Adelman, Karen; Sharp, Phillip A; Young, Richard A; Boutz, Paul L; Zon, Leonard I.
Affiliation
  • Insco ML; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
  • Abraham BJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Dubbury SJ; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Kaltheuner IH; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Dust S; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Wu C; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.
  • Chen KY; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.
  • Liu D; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
  • Bellaousov S; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
  • Cox AM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Martin BJE; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
  • Zhang T; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
  • Ludwig CG; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Fabo T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
  • Modhurima R; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
  • Esgdaille DE; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
  • Henriques T; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
  • Brown KM; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
  • Chanock SJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Geyer M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
  • Adelman K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
  • Sharp PA; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.
  • Young RA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Boutz PL; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Zon LI; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science ; 380(6642): eabn7625, 2023 04 21.
Article in En | MEDLINE | ID: mdl-37079685
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Carcinogens / RNA, Nuclear / CDC2 Protein Kinase / RNA Stability / Melanoma Type of study: Screening_studies Limits: Animals / Humans Language: En Journal: Science Year: 2023 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Carcinogens / RNA, Nuclear / CDC2 Protein Kinase / RNA Stability / Melanoma Type of study: Screening_studies Limits: Animals / Humans Language: En Journal: Science Year: 2023 Type: Article Affiliation country: United States